Improvement of replication fidelity by certain mesalazine derivative
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چکیده
منابع مشابه
Mesalazine improves replication fidelity in cultured colorectal cells.
Epidemiologic studies indicate that mesalazine has chemopreventive effects in inflammatory bowel disease-associated colorectal cancer. Most of our general understanding of chemoprevention in colorectal cancer is, however, derived from aspirin, which is structurally similar to mesalazine. Herein we determined the influence of aspirin and mesalazine on replication fidelity in cultured colorectal ...
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DNA replication fidelity plays fundamental role in faithful transmission of genetic material during cell division and during transfer of genetic material from parents to progeny. Replicative polymerases are the main guardian responsible for high replication fidelity of genomic DNA. DNA main replicative polymerases are also involved in many DNA repair processes. High fidelity of DNA replication ...
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The six billion nucleotides of the diploid human genome are replicated in only a few hours while generating so few errors that the spontaneous mutation rate may be less than 1 mutation per genome per cell division (Loeb 1991). This incredible accuracy results from three major erroravoidance processes: the high selectivity of DNA polymerases, exonucleolytic proofreading, and postreplication mism...
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Background: Caenorhabditis elegans is an important model for the study of DNA damage and repair related processes such as aging, neurodegeneration, and carcinogenesis. However, DNA repair is poorly characterized in this organism. We adapted a quantitative polymerase chain reaction assay to characterize repair of DNA damage induced by ultraviolet type C (UVC) radiation in C. elegans, and then te...
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Making use of a certain operator of fractional derivative, a new subclass Fλ(n, p, α, μ) of analytic and p-valent functions with negative coefficients is introduced and studied here rather systematically. Coefficient estimates, a distortion theorem and radii of p-valently closeto-convexity, starlikeness and convexity are given. Finally several applications involving an integral operator and a c...
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ژورنال
عنوان ژورنال: International Journal of Oncology
سال: 2012
ISSN: 1019-6439,1791-2423
DOI: 10.3892/ijo.2012.1381